Journal article

Gametocyte carriage of Plasmodium falciparum (pfs25) and Plasmodium vivax (pvs25) during mass screening and treatment in West Timor, Indonesia: a longitudinal prospective study

Ayleen Kosasih, Cristian Koepfli, M Sopiyudin Dahlan, William A Hawley, J Kevin Baird, Ivo Mueller, Neil F Lobo, Inge Sutanto

MALARIA JOURNAL | BMC | Published : 2021

Abstract

BACKGROUND: A goal of malaria epidemiological interventions is the detection and treatment of parasite reservoirs in endemic areas-an activity that is expected to reduce local transmission. Since the gametocyte is the only transmissible stage from human host to mosquito vector, this study evaluated the pre and post presence of gametocytes during a mass screening and treatment (MST) intervention conducted during 2013 in East Nusa Tenggara, Indonesia. METHODS: RT-qPCR targeting pfs25 and pvs25 transcripts-gametocyte molecular markers for Plasmodium falciparum and Plasmodium vivax, respectively, was performed to detect and quantify gametocytes in blood samples of P. falciparum and P. vivax-infe..

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University of Melbourne Researchers

Grants

Awarded by Bill & Melinda Gates Foundation through Malaria Transmission Consortium


Awarded by Ministry of Research Technology and Higher Education of Republic of Indonesia


Funding Acknowledgements

The work was supported by Bill & Melinda Gates Foundation through Malaria Transmission Consortium (45114), and the Ministry of Research Technology and Higher Education of Republic of Indonesia (120/SP2H/PTNBH/DRPM/2018).