Journal article
Poly(2-allylamidopropyl-2-oxazoline)-Based Hydrogels: From Accelerated Gelation Kinetics to in Vivo Compatibility in a Murine Subdermal Implant Model
TR Dargaville, DG Harkin, JR Park, A Cavalcanti, ECL Bolle, FM Savi, BL Farrugia, BD Monnery, Y Bernhard, JFR Van Guyse, A Podevyn, R Hoogenboom
Biomacromolecules | AMER CHEMICAL SOC | Published : 2021
Abstract
A rapid photo-curing system based on poly(2-ethyl-2-oxazoline-co-2-allylamidopropyl-2-oxazoline) and its in vivo compatibility are presented. The base polymer was synthesized from the copolymerization of 2-ethyl-2-oxazoline (EtOx) and the methyl ester containing 2-methoxycarboxypropyl-2-oxazoline (C3MestOx) followed by amidation with allylamine to yield a highly water-soluble macromer. We showed that spherical hydrogels can be obtained by a simple water-in-oil gelation method using thiol-ene coupling and investigated the in vivo biocompatibility of these hydrogel spheres in a 28-day murine subdermal model. For comparison, hydrogel spheres prepared from poly(ethylene glycol) were also implant..
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Awarded by Australian Research Council
Funding Acknowledgements
This project was performed with the approval of QUT's Animal Research Ethics Committee (Project approval number: 1900000716). T.D. is supported by the ARC Future Fellowship scheme (FT150100408). This work was enabled by use of the Central Analytical Research Facility hosted by the Institute for Future Environments at QUT. The authors acknowledge the assistance of Auvro Mridha (University of Sydney) with performing the toxicity tests and Justin Large and Emily Goy (Translational Research Institute, Brisbane) for assistance with histology.