Changes in white adipose tissue gene expression in a randomized control trial of dieting obese men with lowered serum testosterone alone or in combination with testosterone treatment
Mathis Grossmann, Mark Ng Tang Fui, Tian Nie, Rudolf Hoermann, Michele V Clarke, Ada S Cheung, Jeffrey D Zajac, Rachel A Davey
ENDOCRINE | SPRINGER | Published : 2021
PURPOSE: The aim of this study was to determine early weight loss-associated changes in subcutaneous abdominal white adipose tissue (WAT) gene expression in obese men with lowered serum testosterone by RNA next-generation sequencing. METHODS: Fourteen men, mean age (IQR) 51.6 years (43.4-54.5), BMI 38.3 kg/m2 (34.6-40.8) and total testosterone 8.4 nmol/L (7.5-9.5) provided subcutaneous WAT samples at baseline and after 2 weeks of a very low energy diet. RESULTS: Body weight loss was similar in participants receiving testosterone (n = 6), -5.27 kg [95% CI -6.17; -4.26], and placebo (n = 8), -4.57 kg [95% CI -6.10; -3.55], p = 0.86. In placebo-treated men, of the 14,410 genes expressed in subc..View full abstract
Bayer Pharma AG (Berlin, Germany) provided testosterone, placebo and financial support to conduct investigations, but had no role in trial design, data analysis or writing the paper.