Journal article

Optimising Antimicrobial Selection and Duration in the Treatment of Febrile Neutropenia in Children

Jessica E Morgan, Bob Phillips, Gabrielle M Haeusler, Julia C Chisholm

Infection and Drug Resistance | DOVE MEDICAL PRESS LTD | Published : 2021

Abstract

Febrile neutropenia (FN) is a frequent complication of cancer treatment in children. Owing to the potential for overwhelming bacterial sepsis, the recognition and management of FN requires rapid implementation of evidenced-based management protocols. Treatment paradigms have progressed from hospitalisation with broad spectrum antibiotics for all patients, through to risk adapted approaches to management. Such risk adapted approaches aim to provide safe care through incorporating antimicrobial stewardship (AMS) principles such as implementation of comprehensive clinical pathways incorporating de-escalation strategies with the imperative to reduce hospital stay and antibiotic exposure where po..

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