Journal article

Neuronal androgen receptor is required for activity dependent enhancement of peripheral nerve regeneration

Patricia J Ward, Rachel A Davey, Jeffrey D Zajac, Arthur W English

DEVELOPMENTAL NEUROBIOLOGY | WILEY | Published : 2021

Abstract

Neuronal activity after nerve injury can enhance axon regeneration and the restoration of function. The mechanism for this enhancement relies in part on hormone receptors, and we previously demonstrated that systemic androgen receptor antagonism blocked the effect of exercise or electrical stimulation on enhancing axon regeneration after nerve injury in both sexes. Here, we tested the hypothesis that the site of this androgen receptor signaling is both neuronal and involves the classical, genomic signaling pathway. In vivo, dorsal root ganglion neurons successfully regenerate in response to activity-dependent neuronal activation, and conditional deletion of the DNA-binding domain of the andr..

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Grants

Awarded by Emory Specialized Center of Research Excellence in Sex Differences


Awarded by National Institute of Neurological Disorders and Stroke


Funding Acknowledgements

Emory Specialized Center of Research Excellence in Sex Differences, Grant/Award Number: U54AG062334; National Institute of Neurological Disorders and Stroke, Grant/Award Number: NS057190 and NS087915