miR-148a weaves its thread into the plasma cell fate
EUROPEAN JOURNAL OF IMMUNOLOGY | WILEY | Published : 2021
The plasma cells (PC) are characterized by their rarity, their formidable capacity to continuously secrete massive amounts of antibodies and the potential to live through the whole life span of the organism that houses them. Because of the potency of their effector function, their differentiation and survival are tightly regulated. The PC identity is implemented and maintained by a transcriptional program that allow them to face the challenges entailed by their longevity and high metabolic activity. The main transcription factors overseeing this transcriptional network have been identified (BLIMP1, IRF4, XBP1), but new players, like miRNA, continue to emerge and bring new layers of complexit..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by the National Health and Medical Research Council of Australia (1144905, 1160830).