Red Blood Cell Fatty Acids and Risk of Colorectal Cancer in The European Prospective Investigation into Cancer and Nutrition (EPIC).
Jakob Linseisen, Nina Grundmann, Dorothee Zoller, Tilman Kühn, Eugène HJM Jansen, Veronique Chajès, Veronika Fedirko, Elisabete Weiderpass, Christina C Dahm, Kim Overvad, Anne Tjønneland, Marie-Christine Boutron-Ruault, Joseph A Rothwell, Gianluca Severi, Rudolf Kaaks, Matthias B Schulze, Krasimira Aleksandrova, Sabina Sieri, Salvatore Panico, Rosario Tumino Show all
Cancer Epidemiol Biomarkers Prev | Published : 2021
BACKGROUND: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer risk. However, data from large-scale epidemiologic studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce. METHODS: We investigate the association between red blood cell (RBC) membrane FAs and risk of colorectal cancer in a case-control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1,069 incident colorectal cancer cases were identified and matched to 1,069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The F..View full abstract