Altered metabolic pathways in a transgenic mouse model suggest mechanistic role of amyloid precursor protein overexpression in Alzheimer's disease
Hattapark Dejakaisaya, Anna Harutyunyan, Patrick Kwan, Nigel C Jones
METABOLOMICS | SPRINGER | Published : 2021
INTRODUCTION: The mechanistic role of amyloid precursor protein (APP) in Alzheimer's disease (AD) remains unclear. OBJECTIVES: Here, we aimed to identify alterations in cerebral metabolites and metabolic pathways in cortex, hippocampus and serum samples from Tg2576 mice, a widely used mouse model of AD. METHODS: Metabolomic profilings using liquid chromatography-mass spectrometry were performed and analysed with MetaboAnalyst and weighted correlation network analysis (WGCNA). RESULTS: Expressions of 11 metabolites in cortex, including hydroxyphenyllactate-linked to oxidative stress-and phosphatidylserine-lipid metabolism-were significantly different between Tg2576 and WT mice (false discover..View full abstract
PK is supported by a Medical Research Future Fund Fellowship; HD is supported by The Scholarship in Commemoration of HM King Bhumibol Adulyadej 90th Birthday Anniversary.