Altered metabolic pathways in a transgenic mouse model suggest mechanistic role of amyloid precursor protein overexpression in Alzheimer’s disease

Abstract

Introduction: The mechanistic role of amyloid precursor protein (APP) in Alzheimer’s disease (AD) remains unclear. Objectives: Here, we aimed to identify alterations in cerebral metabolites and metabolic pathways in cortex, hippocampus and serum samples from Tg2576 mice, a widely used mouse model of AD. Methods: Metabolomic profilings using liquid chromatography-mass spectrometry were performed and analysed with MetaboAnalyst and weighted correlation network analysis (WGCNA). Results: Expressions of 11 metabolites in cortex, including hydroxyphenyllactate—linked to oxidative stress—and phosphatidylserine—lipid metabolism—were significantly different between Tg2576 and WT mice (false discover..