Journal article

Breast cancer screening and overdiagnosis

Jean-Luc Bulliard, Anna-Belle Beau, Sisse Njor, Wendy Yi-Ying Wu, Pietro Procopio, Carolyn Nickson, Elsebeth Lynge

INTERNATIONAL JOURNAL OF CANCER | WILEY | Published : 2021

Abstract

Overdiagnosis is a harmful consequence of screening which is particularly challenging to estimate. An unbiased setting to measure overdiagnosis in breast cancer screening requires comparative data from a screened and an unscreened cohort for at least 30 years. Such randomised data will not become available, leaving us with observational data over shorter time periods and outcomes of modelling. This collaborative effort of the International Cancer Screening Network quantified the variation in estimated breast cancer overdiagnosis in organised programmes with evaluation of both observed and simulated data, and presented examples of how modelling can provide additional insights. Reliable observ..

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