Journal article

Estimated impact of tafenoquine for Plasmodium vivax control and elimination in Brazil: A modelling study

Narimane Nekkab, Raquel Lana, Marcus Lacerda, Thomas Obadia, Andre Siqueira, Wuelton Monteiro, Daniel Villela, Ivo Mueller, Michael White



BACKGROUND: Despite recent intensification of control measures, Plasmodium vivax poses a major challenge for malaria elimination efforts. Liver-stage hypnozoite parasites that cause relapsing infections can be cleared with primaquine; however, poor treatment adherence undermines drug effectiveness. Tafenoquine, a new single-dose treatment, offers an alternative option for preventing relapses and reducing transmission. In 2018, over 237,000 cases of malaria were reported to the Brazilian health system, of which 91.5% were due to P. vivax. METHODS AND FINDINGS: We evaluated the impact of introducing tafenoquine into case management practices on population-level transmission dynamics using a ma..

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University of Melbourne Researchers


Awarded by NHMRC Principal Research Fellowship

Funding Acknowledgements

NN, MW, DV, and RL received funding from the Medicines for Malaria Venture ( NN has been in part supported by the Pasteur-Roux-Cantarini Fellowship by Institut Pasteur ( 2019-autumn-session/). NN, IM, andMWare supported by the Supporting Preparedness in the Asia-Pacific Region through Knowledge (SPARK) project under the ASEAN-Pacific Infectious Disease and Response program (APIDDaR) ( IM is supported by NHMRC Principal Research Fellowship (GNT1155075) ( DV is a CNPq/Brazil research fellow ( funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.