Journal article

Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer: A Systematic Review and Metaanalysis of Oncological and Operative Outcomes

Joseph C Kong, Mikael Soucisse, Michael Michael, Jeanne Tie, Samuel Y Ngan, Trevor Leong, Jacob McCormick, Satish K Warrier, Alexander G Heriot

ANNALS OF SURGICAL ONCOLOGY | SPRINGER | Published : 2021

Abstract

BACKGROUND: Total neoadjuvant therapy in rectal cancer refers to the administration of chemoradiotherapy plus chemotherapy before surgery. Recent studies have shown improved pathological complete response and disease-free survival with this approach. However, survival benefits remain unproven. Our objective is to present a metaanalysis of oncological outcomes of total neoadjuvant therapy in locally advanced rectal cancer. PATIENTS AND METHODS: A comprehensive search was performed on PubMed, Medline, and Google Scholars. Studies comparing total neoadjuvant therapy with standard neoadjuvant chemoradiotherapy were included. Data extracted from the individual studies were pooled and a metaanalys..

View full abstract