Effects of Several Classes of Voltage-Gated Ion Channel Conductances on Gamma and Theta Oscillations in a Hippocampal Microcircuit Model
Chris Olteanu, Forough Habibollahi, Chris French
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2021
Gamma and theta oscillations have been functionally associated with cognitive processes, such as learning and memory. Synaptic conductances play an important role in the generation of intrinsic network rhythmicity, but few studies have examined the effects of voltage-gated ion channels (VGICs) on these rhythms. In this report, we have used a pyramidal-interneuron-gamma (PING) network consisting of excitatory pyramidal cells and two types of inhibitory interneurons. We have constructed a conductance-based neural network incorporating a persistent sodium current (I NaP ), a delayed rectifier potassium current (I KDR ), a inactivating potassium current (I A ) and a hyperpolarization-activated c..View full abstract
This work was supported by the RMH Neuroscience Foundation.