Journal article

Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice

Jeffri S Retamal, Megan S Grace, Larissa K Dill, Paulina Ramirez-Garcia, Scott Peng, Arisbel B Gondin, Felix Bennetts, Sadia Alvi, Pradeep Rajasekhar, Juhura G Almazi, Simona E Carbone, Nigel W Bunnett, Thomas P Davis, Nicholas A Veldhuis, Daniel P Poole, Peter McIntyre

LABORATORY INVESTIGATION | SPRINGERNATURE | Published : 2021

Abstract

Endothelial and epithelial cells form physical barriers that modulate the exchange of fluid and molecules. The integrity of these barriers can be influenced by signaling through G protein-coupled receptors (GPCRs) and ion channels. Serotonin (5-HT) is an important vasoactive mediator of tissue edema and inflammation. However, the mechanisms that drive 5-HT-induced plasma extravasation are poorly defined. The Transient Receptor Potential Vanilloid 4 (TRPV4) ion channel is an established enhancer of signaling by GPCRs that promote inflammation and endothelial barrier disruption. Here, we investigated the role of TRPV4 in 5-HT-induced plasma extravasation using pharmacological and genetic appro..

View full abstract

University of Melbourne Researchers

Grants

Awarded by NHMRC Australia


Funding Acknowledgements

Australian Research Council Center of Excellence in Convergent Bio-Nano Science and Technology (TPD, NWB, and NAV), NHMRC Australia 1046860 (PM, NWB), 1083480 (DPP).