Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice
Jeffri S Retamal, Megan S Grace, Larissa K Dill, Paulina Ramirez-Garcia, Scott Peng, Arisbel B Gondin, Felix Bennetts, Sadia Alvi, Pradeep Rajasekhar, Juhura G Almazi, Simona E Carbone, Nigel W Bunnett, Thomas P Davis, Nicholas A Veldhuis, Daniel P Poole, Peter McIntyre
LABORATORY INVESTIGATION | SPRINGERNATURE | Published : 2021
Endothelial and epithelial cells form physical barriers that modulate the exchange of fluid and molecules. The integrity of these barriers can be influenced by signaling through G protein-coupled receptors (GPCRs) and ion channels. Serotonin (5-HT) is an important vasoactive mediator of tissue edema and inflammation. However, the mechanisms that drive 5-HT-induced plasma extravasation are poorly defined. The Transient Receptor Potential Vanilloid 4 (TRPV4) ion channel is an established enhancer of signaling by GPCRs that promote inflammation and endothelial barrier disruption. Here, we investigated the role of TRPV4 in 5-HT-induced plasma extravasation using pharmacological and genetic appro..View full abstract
Awarded by NHMRC Australia
Australian Research Council Center of Excellence in Convergent Bio-Nano Science and Technology (TPD, NWB, and NAV), NHMRC Australia 1046860 (PM, NWB), 1083480 (DPP).