Journal article
MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis
M Rajasekhar, AM Olsson, KJA Steel, M Georgouli, U Ranasinghe, C Brender Read, KS Frederiksen, LS Taams
Journal of Autoimmunity | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2017
Open access
Abstract
Monocytes and macrophages are key mediators of inflammation in rheumatoid arthritis (RA). Their persistence at the inflammatory site is likely to contribute to immunopathology. We sought to characterise one mechanism by which persistence may be achieved: resistance to apoptosis and the role of mir-155 in this process. CD14+ monocytes from peripheral blood (PBM) and synovial fluid (SFM) of RA patients were found to be resistant to spontaneous apoptosis relative to PBM from healthy control (HC) individuals. RA SFM were also resistant to anti-Fas-mediated apoptosis and displayed a gene expression profile distinct from HC and RA PBM populations. Gene expression profiling analysis revealed that t..
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Awarded by National Institute for Health and Care Research
Funding Acknowledgements
The authors would like to acknowledge Dr Bina Menon for assistance in patient sample collection. This work was supported by a research grant from Novo Nordisk A/S, by a PhD studentship from Arthritis Research UK (grant ref 20960) and by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.