Journal article

Outcomes of protracted bacterial bronchitis in children: A 5-year prospective cohort study

Tom JC Ruffles, Julie M Marchant, Ian B Masters, Stephanie T Yerkovich, Danielle F Wurzel, Peter G Gibson, Greta Busch, Katherine J Baines, Jodie L Simpson, Heidi C Smith-Vaughan, Susan J Pizzutto, Helen M Buntain, Gregory Hodge, Sandra Hodge, John W Upham, Anne B Chang

RESPIROLOGY | WILEY | Published : 2020

Abstract

BACKGROUND AND OBJECTIVE: Long-term data on children with PBB has been identified as a research priority. We describe the 5-year outcomes for children with PBB to ascertain the presence of chronic respiratory disease (bronchiectasis, recurrent PBB and asthma) and identify the risk factors for these. METHODS: Prospective cohort study was undertaken at the Queensland Children's Hospital, Brisbane, Australia, of 166 children with PBB and 28 controls (undergoing bronchoscopy for symptoms other than chronic wet cough). Monitoring was by monthly contact via research staff. Clinical review, spirometry and CT chest were performed as clinically indicated. RESULTS: A total of 194 children were include..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Centre of Research Excellence in preventing and managing bronchiectasis


Awarded by Queensland Children's Hospital Foundation (CHF) fellowship


Awarded by NHMRC


Awarded by CHF top-up fellowship


Funding Acknowledgements

We are grateful to all the parents and children who participated in this study. We also thank Sandy Goodwin for maintaining the database, and Sophie Anderson-James, Helen Petsky and Samantha Prime for collecting the specimens and clinical data. The study was funded by an Australian National Health and Medical Research Council (NHMRC) Project Grant (APP1042601) and NHMRC Centre of Research Excellence in preventing and managing bronchiectasis (APP1170958). J.M.M. is supported by a Queensland Children's Hospital Foundation (CHF) fellowship (RPC0772019). A.B.C. is supported by an NHMRC practitioner fellowship (APP1154302) and CHF top-up fellowship (#50286). None of the authors received an honorarium or other form of payment to produce the manuscript.