Conference Proceedings

Protracted Bacterial Bronchitis in Children Natural History and Risk Factors for Bronchiectasis

Danielle F Wurzel, Julie M Marchant, Stephanie T Yerkovich, John W Upham, Helen L Petsky, Heidi Smith-Vaughan, Brent Masters, Helen Buntain, Anne B Chang

CHEST | ELSEVIER SCIENCE BV | Published : 2016

Abstract

BACKGROUND: Protracted bacterial bronchitis (PBB) and bronchiectasis are distinct diagnostic entities that share common clinical and laboratory features. It is postulated, but remains unproved, that PBB precedes a diagnosis of bronchiectasis in a subgroup of children. In a cohort of children with PBB, our objectives were to (1) determine the medium-term risk of bronchiectasis and (2) identify risk factors for bronchiectasis and recurrent episodes of PBB. METHODS: One hundred sixty-one children with PBB and 25 control subjects were prospectively recruited to this cohort study. A subset of 106 children was followed for 2 years. Flexible bronchoscopy, BAL, and basic immune function tests were p..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Financial Markets Foundation for Children


Awarded by NHMRC


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) [project grant 1042601 and Centre of Research Excellence grant 1040830] and the Financial Markets Foundation for Children [project grant 2010-005]. D. W. was supported by scholarships from the Thoracic Society of Australia and New Zealand/Allen and Hanbury's, Queensland Children's Medical Research Institute and NHMRC [1039688]. A. C. and H. S. V. are supported by NHMRC fellowships [1058213 and 1024175]. The views expressed in this publication are those of the authors and do not reflect the views of the NHMRC.