Adenovirus Species C Is Associated With Chronic Suppurative Lung Diseases in Children
Danielle F Wurzel, Ian M Mackay, Julie M Marchant, Claire YT Wang, Stephanie T Yerkovich, John W Upham, Heidi C Smith-Vaughan, Helen L Petsky, Anne B Chang
CLINICAL INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2014
BACKGROUND: The role of human adenoviruses (HAdVs) in chronic respiratory disease pathogenesis is recognized. However, no studies have performed molecular sequencing of HAdVs from the lower airways of children with chronic endobronchial suppuration. We thus examined the major HAdV genotypes/species, and relationships to bacterial coinfection, in children with protracted bacterial bronchitis (PBB) and mild bronchiectasis (BE). METHODS: Bronchoalveolar lavage (BAL) samples of 245 children with PBB or mild (cylindrical) BE were included in this prospective cohort study. HAdVs were genotyped (when possible) in those whose BAL had HAdV detected (HAdV(+)). Presence of bacterial infection (defined ..View full abstract
Awarded by NHMRC
Awarded by NHMRC (Centre of Research Excellence)
Awarded by Financial Markets Foundation for Children
This work was supported by the NHMRC (project grant 1042601 and Centre of Research Excellence grant 1040830) and the Financial Markets Foundation for Children (project grant 2010-005). D. F. W. is supported by scholarships from the Thoracic Society of Australia and New Zealand/Allen and Hanbury's, Queensland Children's Medical Research Institute and NHMRC (1039688). A. B. C. is supported by NHMRC practitioner fellowships (grants 545216 and 1058213).