Pulmonary Innate Immunity in Children with Protracted Bacterial Bronchitis
Anne B Chang, Stephanie T Yerkovich, Peter G Gibson, Sophie Anderson-James, Helen L Petsky, Melanie L Carroll, I Brent Masters, Julie M Marchant, Danielle Wurzel, John W Upham
JOURNAL OF PEDIATRICS | MOSBY-ELSEVIER | Published : 2012
OBJECTIVE: To determine bronchoalveolar lavage (BAL) levels of 3 innate immunity components (human β-defensin-2 [hBD2], mannose-binding lectin [MBL], and surfactant protein-A [SP-A]), the relationship with airway neutrophilia and infection, and cytokine production of stimulated BAL cells in children with current protracted bacterial bronchitis (PBB), children with resolved PBB (PBB well), and controls. STUDY DESIGN: BAL of 102 children (mean age 2.8 years) fulfilling predefined criteria of current PBB (n = 61), PBB well (n = 20), and controls (n = 21) was cultured (quantitative bacteriology) and viruses examined by polymerase chain reaction. hBD2, MBL, and SP-A were measured, and cytokine pr..View full abstract
Awarded by Financial Markets Foundation for Children
Awarded by National Health and Medical Research Council
Funded by the Financial Markets Foundation for Children (grant 2010-005) and the Royal Children's Hospital Foundation. A.C. (grant 545216), P.G. (grant 569240), and J.U. (grant 511019) are supported by National Health and Medical Research Council fellowships. The study sponsors had no role in study design; the collection, analysis, and interpretation of data; the writing of the report; or the decision to submit the paper for publication. The authors declare no conflicts of interest.