Journal article

Wet Cough in Children: Infective and Inflammatory Characteristics in Broncho-Alveolar Lavage

Danielle F Wurzel, Julie M Marchant, Julia E Clark, I Brent Masters, Stephanie T Yerkovich, John W Upham, Anne B Chang



Wet cough is a common feature of many disease processes affecting children. Our aim was to examine the relationships between cough nature, lower airway infection (bacterial, viral, and viral-bacterial) and severity of neutrophilic airway inflammation. We hypothesized that viral-bacterial co-infection of the lower airway would be associated with wet cough and heightened neutrophilic airway inflammation. We prospectively recruited 232 children undergoing elective flexible bronchoscopy. Participants were grouped using a cough nature symptom-based approach, into wet, dry or no cough groups. Broncho-alveolar lavage (BAL) and clinical data, including presence, nature, and duration of cough and key..

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

D. Wurzel received funding from Thoracic Society of Australia and New Zealand/Allen and Hanbury's Paediatric Respiratory grant-in-aid; National Health and Medical Research Council (NHMRC) post-graduate scholarship (GNT1039688) and Queensland Children's Medical Research Institute. A. Chang (545216) and J. Upham (511019) are supported by NHMRC fellowships.