Wet Cough in Children: Infective and Inflammatory Characteristics in Broncho-Alveolar Lavage
Danielle F Wurzel, Julie M Marchant, Julia E Clark, I Brent Masters, Stephanie T Yerkovich, John W Upham, Anne B Chang
PEDIATRIC PULMONOLOGY | WILEY | Published : 2014
Wet cough is a common feature of many disease processes affecting children. Our aim was to examine the relationships between cough nature, lower airway infection (bacterial, viral, and viral-bacterial) and severity of neutrophilic airway inflammation. We hypothesized that viral-bacterial co-infection of the lower airway would be associated with wet cough and heightened neutrophilic airway inflammation. We prospectively recruited 232 children undergoing elective flexible bronchoscopy. Participants were grouped using a cough nature symptom-based approach, into wet, dry or no cough groups. Broncho-alveolar lavage (BAL) and clinical data, including presence, nature, and duration of cough and key..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC
D. Wurzel received funding from Thoracic Society of Australia and New Zealand/Allen and Hanbury's Paediatric Respiratory grant-in-aid; National Health and Medical Research Council (NHMRC) post-graduate scholarship (GNT1039688) and Queensland Children's Medical Research Institute. A. Chang (545216) and J. Upham (511019) are supported by NHMRC fellowships.