Journal article

Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes

Marc-Jan Gubbels, Caroline D Keroack, Sriveny Dangoudoubiyam, Hanna L Worliczek, Aditya S Paul, Clara Bauwens, Brendan Elsworth, Klemens Engelberg, Daniel K Howe, Isabelle Coppens, Manoj T Duraisingh

Frontiers in Cellular and Infection Microbiology | Frontiers Media | Published : 2020

Abstract

Cellular reproduction defines life, yet our textbook-level understanding of cell division is limited to a small number of model organisms centered around humans. The horizon on cell division variants is expanded here by advancing insights on the fascinating cell division modes found in the Apicomplexa, a key group of protozoan parasites. The Apicomplexa display remarkable variation in offspring number, whether karyokinesis follows each S/M-phase or not, and whether daughter cells bud in the cytoplasm or bud from the cortex. We find that the terminology used to describe the various manifestations of asexual apicomplexan cell division emphasizes either the number of offspring or site of buddin..

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University of Melbourne Researchers

Grants

Awarded by National Science Foundation (NSF) Major Research Instrumentation grant


Awarded by National Institute of Health


Awarded by American Heart Association


Awarded by University of Veterinary Medicine Vienna


Awarded by USDA NIFA



Funding Acknowledgements

This study was supported by National Science Foundation (NSF) Major Research Instrumentation grant 1626072, National Institute of Health grants AI110690 (M-JG), AI110638 (M-JG), AI128136 (M-JG), AI144856 (M-JG), and AI128480 (MD), an American Heart Association predoctoral fellowship19PRE34380106 (CK), a Profillinien start-up grant of the University of Veterinary Medicine Vienna PP16110262 (HW), an Australian NHMRC CJ Martin fellowship (BE), a post-doctoral fellowship grant 17POST33670577 (KE), a Knights Templar Eye Foundation Career Starter Award (KE), and USDA NIFA grant 2009-6510905918 (DH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.