To kill a piroplasm: genetic technologies to advance drug discovery and target identification in Babesia
Caroline D Keroack, Brendan Elsworth, Manoj T Duraisingh
INTERNATIONAL JOURNAL FOR PARASITOLOGY | ELSEVIER SCI LTD | Published : 2019
Babesia parasites infect a diverse range of vertebrate hosts, from penguins to pigs. Recently, the emergence of zoonotic Babesia infection has been increasing, and the list of species reported to infect humans continues to grow. Babesiosis represents a burgeoning veterinary and medical threat, and the need for novel therapeutic drugs to effectively target this diverse group of parasites is pressing. Here, we review the current culture systems that exist to study and manipulate Babesia parasites, and identify the scope and methods for target discovery and validation to identify novel, potent anti-babesial inhibitors. Challenges exist including difficulties in the culture systems of important ..View full abstract
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Awarded by Australian National Health and Medical Research Council CJ Martin fellowship
Awarded by National Institute of Health, USA
Brendan Elsworth was supported by an Australian National Health and Medical Research Council CJ Martin fellowship (#1148392). Caroline D. Keroack was supported by a National Institute of Health, USA, training grant (#5T32AI49928-13).