Temporal Quantitative Proteomics Analysis of Neuroblastoma Cells Treated with Bovine Milk-Derived Extracellular Vesicles Highlights the Anti-Proliferative Properties of Milk-Derived Extracellular Vesicles
Pamali Fonseka, Taeyoung Kang, Sing Chee, Sai V Chitti, Rahul Sanwlani, Ching-Seng Ang, Suresh Mathivanan
Cells | MDPI | Published : 2021
Neuroblastoma (NBL) is a pediatric cancer that accounts for 15% of childhood cancer mortality. Amplification of the oncogene N-Myc occurs in 20% of NBL patients and is considered high risk as it correlates with aggressiveness, treatment resistance and poor prognosis. Even though the treatment strategies have improved in the recent years, the survival rate of high-risk NBL patients remain poor. Hence, it is crucial to explore new therapeutic avenues to sensitise NBL. Recently, bovine milk-derived extracellular vesicles (MEVs) have been proposed to contain anti-cancer properties. However, the impact of MEVs on NBL cells is not understood. In this study, we characterised MEVs using Western blot..View full abstract
Awarded by Australian Research Council Future Fellowship
Suresh Mathivanan is supported by Australian Research Council Future Fellowship (FT180100333) but the project was not funded by the basic science grants. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Pamali Fonseka is supported by CASS Foundation Medicine/Science Grant.