Journal article

The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin

Leila N Varghese, Jean-Philippe Defour, Christian Pecquet, Stefan N Constantinescu



A well-functioning hematopoietic system requires a certain robustness and flexibility to maintain appropriate quantities of functional mature blood cells, such as red blood cells and platelets. This review focuses on the cytokine receptor that plays a significant role in thrombopoiesis: the receptor for thrombopoietin (TPO-R; also known as MPL). Here, we survey the work to date to understand how this receptor functions at a molecular level throughout its lifecycle, from traffic to the cell surface, dimerization and binding cognate cytokine via its extracellular domain, through to its subsequent activation of associated Janus kinases and initiation of downstream signaling pathways, as well as..

View full abstract

University of Melbourne Researchers


Awarded by Action de Recherche Concertee project of the Universite catholique de Louvain

Awarded by PAI Programs

Funding Acknowledgements

Support is acknowledged to SC from Ludwig Institute for Cancer Research, FRS-FNRS, Salus Sanguinis Foundation, the Action de Recherche Concertee project ARC10/15-027 of the Universite catholique de Louvain, the Fondation contre le Cancer, the PAI Programs BCHM61B5 and Belgian Medical Genetics Initiative. J-PD was supported by a FRIA Fellowship and by Cliniques universitaires St Luc. LV was supported by a Haas-Teichen postdoctoral fellowship, a postdoctoral fellowship from the Maurange Fund at de Duve Institute and a Move-In Louvain postdoctoral fellowship from the Universite catholique de Louvain.