Journal article
STIM1 is necessary for store-operated calcium entry in turning growth cones
CB Mitchell, RJ Gasperini, DH Small, L Foa
Journal of Neurochemistry | WILEY | Published : 2012
Abstract
Coordinated calcium signalling is vital for neuronal growth cone function and axon pathfinding. Although store-operated calcium entry (SOCE) has been suggested to be an important source of calcium in growth cone navigation, the mechanisms that regulate calcium signalling, particularly the regulation of internal calcium stores within growth cones, are yet to be fully determined. Stromal Interaction Molecule 1 (STIM1) is a calcium-sensing protein localized in the endoplasmic reticulum membrane that interacts with Orai proteins in the plasma membrane to initiate SOCE and refilling of intracellular calcium stores. We hypothesize that STIM1- and Orai1/2-mediated SOCE are necessary for growth cone..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors declare that they have no conflicts of interest. The authors thank members of the Foa and Small laboratories for their help in the preparation of this manuscript. The work was supported by grants from the Ian Potter Foundation and the National Health and Medical Research Council (512801 and 1024145) to LF. CBM is supported by an Australian Postgraduate Award.