Antitumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma in vivo.
Jianmin Qin, Lin Yang, Xia Sheng, Zhongqiu Sa, Tao Huang, Qi Li, Kepan Gao, Qinghua Chen, Jingwei Ma, Hebai Shen
Oncology Letters | Published : 2018
In vitro and in vivo studies have demonstrated that brucine is able to inhibit the proliferation of liver cancer cells and growth of animal tumors, and may be a promising anticancer drug. However, high toxicity, poor water solubility, short half-life, narrow therapeutic window, and similar therapeutic and toxic doses limit its clinical application in the treatment of malignant tumors. In our previous study, brucine immuno-nanoparticles were successfully prepared and added to the culture medium of liver cancer SMMC-7721 cells, and the results indicated that the brucine immuno-nanoparticles were able to target the cell membrane of liver cancer SMMC-7721 cells and significantly inhibit the prol..View full abstract