PET imaging detection of macrophages with a formyl peptide receptor antagonist.
Yi Zhang, Bijoy Kundu, Min Zhong, Tao Huang, Jing Li, Mahendra D Chordia, Mei-Hua Chen, Dongfeng Pan, Jiang He, Weibin Shi
Nuclear Medicine and Biology | Published : 2015
Macrophages are a major inflammatory cell type involved in the development and progression of many important chronic inflammatory diseases. We previously found that apolipoprotein E-deficient (Apoe(-/-)) mice with the C57BL/6 (B6) background develop type 2 diabetes mellitus (T2DM) and accelerated atherosclerosis when fed a Western diet and that there are increased macrophage infiltrations in pancreatic islets and aorta. The formyl peptide receptor 1 (FPR1) is abundantly expressed on the surface of macrophages. The purpose of this study was to evaluate the applicability of cinnamoyl-F-(D)L-F-(D)L-F (cFLFLF), a natural FPR1 antagonist, to detection of macrophages in the pancreatic islets and a..View full abstract