Anti-tumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma.
Jian-Min Qin, Pei-Hao Yin, Qi Li, Zhong-Qiu Sa, Xia Sheng, Lin Yang, Tao Huang, Min Zhang, Ke-Pan Gao, Qing-Hua Chen, Jing-Wei Ma, He-Bai Shen
International Journal of Nanomedicine | Published : 2012
BACKGROUND: Hepatocellular carcinoma is difficult to diagnose early, and most patients are already in the late stages of the disease when they are admitted to hospital. The total 5-year survival rate is less than 5%. Recent studies have showed that brucine has a good anti-tumor effect, but high toxicity, poor water solubility, short half-life, narrow therapeutic window, and a toxic dose that is close to the therapeutic dose, which all limit its clinical application. This study evaluated the effects of brucine immuno-nanoparticles (BIN) on hepatocellular carcinoma. MATERIALS AND METHODS: Anionic polymerization, chemical modification technology, and phacoemulsification technology were used to ..View full abstract