Effects of material and surface functional group on collagen self-assembly and subsequent cell adhesion behaviors.
Jing He, Yao Su, Tao Huang, Bo Jiang, Fang Wu, Zhongwei Gu
Colloids and Surfaces B Biointerfaces | Published : 2014
Collagen fibrous network not only provides structural support for cells but also serves as critical environment modulating various cell functions. Various factors would influence the collagen self-assembly but the effect of substrate surface on such process has been rarely studied. Here we examined the effects of materials (Ti and hydroxyapatite) and their surface characteristics (with and without the enrichment of hydroxyl group) on collagen self-reconstitution and fibrous network formation, and on subsequent cell adhesion and cytoskeleton organization of mesenchymal stem cells (MSCs). For both Ti and hydroxyapatite (HA) substrates, the enrichment of hydroxyl group (OH) on substrate surface..View full abstract