Collagen-infiltrated porous hydroxyapatite coating and its osteogenic properties: in vitro and in vivo study.
Jing He, Tao Huang, Lu Gan, Zongke Zhou, Bo Jiang, Yao Wu, Fang Wu, Zhongwei Gu
Journal of Biomedical Materials Research Part A | Published : 2012
Bone-implant interface is critical for the early fixation of orthopedic implants. In this study, porous hydroxyapatite (HA) coatings were prepared through a liquid precursor plasma spraying process and were infiltrated with the collagen, alone and with the additional incorporation of recombinant human bone morphogenetic protein-2 (rhBMP-2) and RGD peptide (RGD). The results showed significantly improved mesenchymal stem cell (MSC) adhesion, proliferation, and differentiation on collagen-modified HA coatings, partially benefited from the formation of a fibrous network due to the self-reconstitution of collagen on the HA surface. Further enhancements on MSC proliferation and differentiation we..View full abstract