Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies.
Rajkumar Dorajoo, Xuling Chang, Resham Lal Gurung, Zheng Li, Ling Wang, Renwei Wang, Kenneth B Beckman, Jennifer Adams-Haduch, Yiamunaa M, Sylvia Liu, Wee Yang Meah, Kar Seng Sim, Su Chi Lim, Yechiel Friedlander, Jianjun Liu, Rob M van Dam, Jian-Min Yuan, Woon-Puay Koh, Chiea Chuen Khor, Chew-Kiat Heng
Nature Communications | Published : 2019
Genetic factors underlying leukocyte telomere length (LTL) may provide insights into telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of 23,096 Singaporean Chinese samples identifies 10 genome-wide loci (P < 5 × 10-8). Several of these contain candidate genes (TINF2, PARP1, TERF1, ATM and POT1) with potential roles in telomere biology and DNA repair mechanisms. Meta-analyses with additional 37,505 European individuals reveals six more genome-wide loci, including associations at MPHOSPH6, NKX2-3 and TYMS. We demonstrate that longer LTL associates with protection against respiratory disease mortality [HR = 0.854(0.804-0.906), P = 1.88 × 10-7] in the Singapo..View full abstract