Journal article

Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies.

Rajkumar Dorajoo, Xuling Chang, Resham Lal Gurung, Zheng Li, Ling Wang, Renwei Wang, Kenneth B Beckman, Jennifer Adams-Haduch, Yiamunaa M, Sylvia Liu, Wee Yang Meah, Kar Seng Sim, Su Chi Lim, Yechiel Friedlander, Jianjun Liu, Rob M van Dam, Jian-Min Yuan, Woon-Puay Koh, Chiea Chuen Khor, Chew-Kiat Heng

Nature Communications | Published : 2019

Abstract

Genetic factors underlying leukocyte telomere length (LTL) may provide insights into telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of 23,096 Singaporean Chinese samples identifies 10 genome-wide loci (P < 5 × 10-8). Several of these contain candidate genes (TINF2, PARP1, TERF1, ATM and POT1) with potential roles in telomere biology and DNA repair mechanisms. Meta-analyses with additional 37,505 European individuals reveals six more genome-wide loci, including associations at MPHOSPH6, NKX2-3 and TYMS. We demonstrate that longer LTL associates with protection against respiratory disease mortality [HR = 0.854(0.804-0.906), P = 1.88 × 10-7] in the Singapo..

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University of Melbourne Researchers