Journal article

Gene-diet interaction effects on BMI levels in the Singapore Chinese population.

Xuling Chang, Rajkumar Dorajoo, Ye Sun, Yi Han, Ling Wang, Chiea-Chuen Khor, Xueling Sim, E-Shyong Tai, Jianjun Liu, Jian-Min Yuan, Woon-Puay Koh, Rob M van Dam, Yechiel Friedlander, Chew-Kiat Heng

Nutrition Journal | Published : 2018


BACKGROUND: Recent genome-wide association studies (GWAS) have identified 97 body-mass index (BMI) associated loci. We aimed to evaluate if dietary intake modifies BMI associations at these loci in the Singapore Chinese population. METHODS: We utilized GWAS information from six data subsets from two adult Chinese population (N = 7817). Seventy-eight genotyped or imputed index BMI single nucleotide polymorphisms (SNPs) that passed quality control procedures were available in all datasets. Alternative Healthy Eating Index (AHEI)-2010 score and ten nutrient variables were evaluated. Linear regression analyses between z score transformed BMI (Z-BMI) and dietary factors were performed. Interactio..

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University of Melbourne Researchers