Journal article

Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia.

Yi Han, Rajkumar Dorajoo, Xuling Chang, Ling Wang, Chiea-Chuen Khor, Xueling Sim, Ching-Yu Cheng, Yuan Shi, Yih Chung Tham, Wanting Zhao, Miao Ling Chee, Charumathi Sabanayagam, Miao Li Chee, Nicholas Tan, Tien Yin Wong, E-Shyong Tai, Jianjun Liu, Daniel YT Goh, Jian-Min Yuan, Woon-Puay Koh Show all

Scientific Reports | Published : 2017


Recent genome-wide association studies (GWAS) have identified multiple loci associated with coronary artery disease (CAD) among predominantly Europeans. However, their relevance to multi-ethnic populations from Southeast Asia is largely unknown. We performed a meta-analysis of four GWAS comprising three Chinese studies and one Malay study (Total N = 2,169 CAD cases and 7,376 controls). Top hits (P  T, G185C) in APOA5 for CAD that reached robust genome-wide significance (Meta P = 7.09 × 10-10, OR = 1.636). Conditional probability analysis indicated that the association at rs2075291 was independent of previously reported index SNP rs964184 in APOA5. We further replicated 10 loci previously ide..

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University of Melbourne Researchers