Interaction effects between Paraoxonase 1 variants and cigarette smoking on risk of coronary heart disease in a Singaporean Chinese population.
Yi Han, Rajkumar Dorajoo, Tingjing Ke, Burger Ayala, Xuling Chang, Chiea-Chuen Khor, Rob M van Dam, Jian-Min Yuan, Woon-Puay Koh, Jianjun Liu, Daniel YT Goh, Yechiel Friedlander, Chew-Kiat Heng
Atherosclerosis | Published : 2015
OBJECTIVE: Paraoxonase 1 (PON1) plays an important role in reducing the risk of coronary heart disease (CHD). Smoking is known to reduce PON1 activity. We aimed to investigate the effects of interactions between PON1 variants and smoking on CHD in the Singaporean Chinese population. METHODS: In a case-control study nested within Singapore Chinese Health Study (N=1914), subjects with and without CHD were classified into never-smokers and ever-smokers (ever smoked at least one cigarette a day for 1 year or longer). Associations at four independent SNPs at the PON1 locus (rs3735590, rs3917550, rs662, rs3917481) with CHD were evaluated using logistic regression, before/after stratification on sm..View full abstract
Awarded by NCI NIH HHS