Journal article

Synchronized oscillations in growing cell populations are explained by demographic noise

Enrico Gavagnin, Sean T Vittadello, Gency Gunasingh, Nikolas K Haass, Matthew J Simpson, Tim Rogers, Christian A Yates

Biophysical Journal | CELL PRESS | Published : 2021

Abstract

Understanding synchrony in growing populations is important for applications as diverse as epidemiology and cancer treatment. Recent experiments employing fluorescent reporters in melanoma cell lines have uncovered growing subpopulations exhibiting sustained oscillations, with nearby cells appearing to synchronize their cycles. In this study, we demonstrate that the behavior observed is consistent with long-lasting transient phenomenon initiated and amplified by the finite-sample effects and demographic noise. We present a novel mathematical analysis of a multistage model of cell growth, which accurately reproduces the synchronized oscillations. As part of the analysis, we elucidate the tran..

View full abstract

University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council


Awarded by Australian Research Council Discovery Program


Funding Acknowledgements

E.G. was supported by the Santander Travel Award. N.K.H. is a Cameron fellow of the Melanoma and Skin Cancer Research Institute of Australia and is supported by the National Health and Medical Research Council (APP1084893). M.J.S. is supported by the Australian Research Council Discovery Program (DP170100474). T.R. acknowledges the support of the Royal Society.