Systematic Identification and Analysis of Acinetobacter baumannii Type VI Secretion System Effector and Immunity Components.
Jessica M Lewis, Deanna Deveson Lucas, Marina Harper, John D Boyce
Frontiers in Microbiology | Published : 2019
Many Gram-negative bacteria use a type VI secretion system (T6SS) for microbial warfare and/or host manipulation. Acinetobacter baumannii is an important nosocomial pathogen and many A. baumannii strains utilize a T6SS to deliver toxic effector proteins to surrounding bacterial cells. These toxic effectors are usually delivered together with VgrG proteins, which form part of the T6SS tip complex. All previously identified A. baumannii T6SS effectors are encoded within a three- or four-gene locus that also encodes a cognate VgrG and immunity protein, and sometimes a chaperone. In order to characterize the diversity and distribution of T6SS effectors and immunity proteins in this species, we f..View full abstract