Journal article

The mRNA expression of insulin -like growth factor-1 (Igfl) is decreased in the rat frontal cortex following gamma-hydroxybutyrate (GHB) administration

Erika Brolin, Jenny Johansson, Sofia Zelleroth, Shanti Diwakarla, Fred Nyberg, Alfhild Gronbladh, Mathias Hallberg

NEUROSCIENCE LETTERS | ELSEVIER IRELAND LTD | Published : 2017

Abstract

In recent years, growth hormone (GH), together with its secondary mediators insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-2 (IGF-2), have been highlighted for their beneficial effects in the central nervous system (CNS), in particular as cognitive enhancers. Cognitive processes, such as learning and memory, are known to be impaired in individuals suffering from substance abuse. In the present study, we investigated the effect of gamma-hydroxybuturate (GHB), an illicit drug used for its sedating and euphoric properties, on genes associated with the somatotrophic axis in regions of the brain important for cognitive function. Sprague Dawley rats (n=36) were divided into th..

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University of Melbourne Researchers