The mRNA expression of insulin -like growth factor-1 (Igfl) is decreased in the rat frontal cortex following gamma-hydroxybutyrate (GHB) administration
Erika Brolin, Jenny Johansson, Sofia Zelleroth, Shanti Diwakarla, Fred Nyberg, Alfhild Gronbladh, Mathias Hallberg
NEUROSCIENCE LETTERS | ELSEVIER IRELAND LTD | Published : 2017
In recent years, growth hormone (GH), together with its secondary mediators insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-2 (IGF-2), have been highlighted for their beneficial effects in the central nervous system (CNS), in particular as cognitive enhancers. Cognitive processes, such as learning and memory, are known to be impaired in individuals suffering from substance abuse. In the present study, we investigated the effect of gamma-hydroxybuturate (GHB), an illicit drug used for its sedating and euphoric properties, on genes associated with the somatotrophic axis in regions of the brain important for cognitive function. Sprague Dawley rats (n=36) were divided into th..View full abstract
Awarded by Swedish Research Council
We would like to thank Anja Sandstrom and Anna-Karin Belfrage at the Department of Medicinal Chemistry, Uppsala University, for technical assistance. We acknowledge the Kjell and Marta Beijers Foundation, C. Swarts Foundation, Carl Tryggers Foundation, and the Swedish Research Council (Grant 9459) for financial support.