Journal article

Bone resorption and dietary calcium in pregnancy-a window to future maternal bone health

EC O'Brien, AA Geraghty, MT Kilbane, MJ McKenna, FM McAuliffe

Osteoporosis International | SPRINGER LONDON LTD | Published : 2021


BACKGROUND: Pregnancy is characterized by increased bone turnover and reversible loss of bone mineral density (BMD) to meet fetal calcium demands. The long-term effect of bone turnover and maternal diet in pregnancy on maternal bone is not well established. OBJECTIVE: We aimed to determine if an association exists between [1] bone resorption, [2] dietary calcium, and [3] serum 25-hydroxyvitamin D in pregnancy with maternal BMD 5-year postpartum. DESIGN: This is a prospective, longitudinal study of 107 women recruited to the ROLO low glycemic index dietary intervention trial in pregnancy and followed-up at 13, 28, and 34 weeks' gestation and 5 years' postpartum. At 13 and 28 weeks' gestation,..

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Awarded by European Union

Funding Acknowledgements

This study was supported by the Health Research Centre for Health and Diet Research (Health Research Board Ireland), The National Maternity Hospital Medical Fund and the European Union's Seventh Framework Programme (FP7/2007-2013), project EarlyNutrition under grant agreement no. 289346. The funding sources had no involvement in the study.