An investigation into nicotinic receptor involvement in mood disorders uncovers novel depression candidate genes
Andrew Gibbons, Kate McPherson, Andrea Gogos, Brian Dean
Journal of Affective Disorders | ELSEVIER | Published : 2021
BACKGROUND: We have previously reported reduced expression of the cholinergic autoreceptor CHRM2 in Brodmann's Area (BA) 24 of the anterior cingulate cortex from subjects with major depressive disorder (MDD) and bipolar disorder (BD), consistent with a hypercholinergic state. This led us to investigate whether levels of the high affinity nicotinic acetylcholine receptors are also altered in BA 24. METHODS: We measured the binding levels of a high-affinity nicotinic receptor-selective radioligand, [3H]epibatidine, in BA 24 from subjects with MDD (n = 20), BD (n = 18) and age- and sex-matched controls (n = 20). We used qPCR to measure mRNA expression of the high affinity nicotinic acetylcholin..View full abstract
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Awarded by National Health and Medical Research Council (Australia)
This project was supported by the National Health and Medical Research Council (Australia; project grant 1105332, Fellowship (BD) APP1002240) and the Victorian Government's Operational Infrastructure Support Programme.