Journal article

The Cellular Organization of the Mammary Gland: Insights From Microscopy

Caleb A Dawson, Jane E Visvader

Journal of Mammary Gland Biology and Neoplasia | SPRINGER/PLENUM PUBLISHERS | Published : 2021

Abstract

Despite rapid advances in our knowledge of the cellular heterogeneity and molecular regulation of the mammary gland, how these relate to 3D cellular organization remains unclear. In addition to hormonal regulation, mammary gland development and function is directed by para- and juxtacrine signaling among diverse cell-types, particularly the immune and mesenchymal populations. Precise mapping of the cellular landscape of the breast will help to decipher this complex coordination. Imaging of thin tissue sections has provided foundational information about cell positioning in the mammary gland and now technological advances in tissue clearing and subcellular-resolution 3D imaging are painting a..

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University of Melbourne Researchers

Grants

Awarded by NHMRC Fellowships


Funding Acknowledgements

J.E.V. was supported by NHMRC Fellowships #1037230 and #1102742.