The Cellular Organization of the Mammary Gland: Insights From Microscopy
Caleb A Dawson, Jane E Visvader
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | SPRINGER/PLENUM PUBLISHERS | Published : 2021
Despite rapid advances in our knowledge of the cellular heterogeneity and molecular regulation of the mammary gland, how these relate to 3D cellular organization remains unclear. In addition to hormonal regulation, mammary gland development and function is directed by para- and juxtacrine signaling among diverse cell-types, particularly the immune and mesenchymal populations. Precise mapping of the cellular landscape of the breast will help to decipher this complex coordination. Imaging of thin tissue sections has provided foundational information about cell positioning in the mammary gland and now technological advances in tissue clearing and subcellular-resolution 3D imaging are painting a..View full abstract
Awarded by NHMRC Fellowships
J.E.V. was supported by NHMRC Fellowships #1037230 and #1102742.