Identifying Molecular Mechanisms of the Late-Phase Asthmatic Response by Integrating Cellular, Gene, and Metabolite Levels in Blood.
Amrit Singh, Casey P Shannon, Young Woong Kim, Mari L DeMarco, Gail M Gauvreau, J Mark FitzGerald, Louis-Philippe Boulet, Paul M O'Byrne, Kim-Anh Le Cao, Scott J Tebbutt
Ann Am Thorac Soc | Published : 2016
RATIONALE: Individuals with allergic asthma respond differently, but reproducibly, to allergen inhalation challenge. Some individuals develop an isolated early response (early responders) (ERs), whereas others go on to develop a late response (dual responders) (DRs). It is not understood why late responses do not develop in all sensitized individuals. OBJECTIVES: The aim of this study was to identify blood biomarkers that can discriminate ERs and DRs using cellular frequencies and gene and metabolite expression from whole blood. METHODS: Thirty-two individuals participated in the allergen inhalation challenge as part of the AllerGen Clinical Investigator Collaborative. Fifteen participants w..View full abstract