Thesis / Dissertation

Genetic and pharmacological targeting of Heat shock protein 72 (Hsp72) in the 5xFAD*Tg30 mouse model of Alzheimer’s disease

Jessica Peta Suan Marshall, Paul Adlard (ed.)

Published : 2020

Abstract

The impact of Alzheimer’s disease (AD) is profound. In Australia, around 460,000 patients have dementia, AD being the most common form. An estimated 1.2 million people are involved in their care and it is the second leading cause of death. It is difficult to provide statistics purely on AD due to the difficulty in diagnosis, but an estimated 70% of dementia cases are AD (322,000 patients) (Dementia Australia 2018). Overexpression of the cytoprotective Heat Shock Protein 72 (Hsp72) is currently under investigation as a potential therapeutic option for prevention and treatment of AD due to its many protective mechanisms. The series of projects in this thesis aim to better understand the effect..

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