Journal article

Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones ofKlebsiella pneumoniae

Kelly Wyres, Ryan Wick, Louise Judd, Roni Froumine, Alex Tokolyi, Claire Gorrie, Margaret Lam, Sebastián Duchêne, Adam Jenney, Kathryn Holt

Published : 2018

Abstract

Klebsiella pneumoniae ( Kp ) has emerged as an important cause of two distinct public health threats: multidrug resistant (MDR) healthcare-associated infections 1 and community-acquired invasive infections, particularly pyogenic liver abscess 2 . The majority of MDR hospital outbreaks are caused by a subset of Kp clones with a high prevalence of acquired antimicrobial resistance (AMR) genes, while the majority of community-acquired invasive infections are caused by ‘hypervirulent’ clones that rarely harbour acquired AMR genes but have high prevalence of key virulence loci 3–5 . Worryingly, the last few years have seen increasing reports of convergence of MDR and the key virulence genes withi..

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