Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide

Sook-Lei Liew; Artemis Zavaliangos-Petropulu; Nicolas Schweighofer; Neda Jahanshad; Catherine Lang; Keith Lohse; Nerisa Banaj; Giuseppe Barisano; Lee Baugh; Anup Bhattacharya; Bavrina Bigjahan; Michael Borich; Lara Boyd; Amy Brodtmann; Cathrin Buetefisch; Winston Byblow; Jessica Cassidy; Valentina Ciullo; Adriana Conforto; Richard Craddock; Adrienne Dula; Natalia Egorova; Wuwei Feng; Kelene Fercho; Chris Gregory; Colleen Hanlon; Kathryn Hayward; Jess Holguin; Brenton Hordacre; Darryl Hwang; Steven Kautz; Mohamed Salah Khlif; Bokkyu Kim; Hosung Kim; Amy Kuceyeski; Bethany Lo; Jingchun Liu; David Lin; Martin Lotze; Bradley MacIntosh; John Margetis; Feroze Mohamed; Jan Egil Nordvik; Matthew Petoe; Fabrizio Piras; Sharmila Raju; Ander Ramos-Murguialday; Kate Revill; Pamela Roberts; Andrew Robertson; Heidi Schambra; Na Jin Seo; Mark Shiroishi; Surjo Soekadar; Gianfranco Spalletta; Cathy Stinear; Anisha Suri; Wai Kwong Tang; Gregory Thielman; Vincent Thijs; Daniela Vecchio; Junping Wang; Nick Ward; Lars Westlye; Carolee Winstein; George Wittenberg; Kristin Wong; Chunshui Yu; Steven Wolf; Steven Cramer; Paul Thompson

Journal article

Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide

Sook-Lei Liew, Artemis Zavaliangos-Petropulu, Nicolas Schweighofer, Neda Jahanshad, Catherine Lang, Keith Lohse, Nerisa Banaj, Giuseppe Barisano, Lee Baugh, Anup Bhattacharya, Bavrina Bigjahan, Michael Borich, Lara Boyd, Amy Brodtmann, Cathrin Buetefisch, Winston Byblow, Jessica Cassidy, Valentina Ciullo, Adriana Conforto, Richard Craddock Show all

Cold Spring Harbor Laboratory | Published : 2020

DOI: 10.1101/2020.11.04.366856

Abstract

ABSTRACT Background and Purpose Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Subcortical regions play critical roles in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of spared subcortical nuclei and sensorimotor behavior at different timepoints after stroke. Methods We pooled high-resolution T1-weighted MRI brain scans and behavioral data in 828 individuals with unilateral stroke from 28 cohorts worldwide. Cross-sectional analyses using linear mixed-effects models related post-stroke sensorimo..

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