Journal article

CD49d marks Th1 and Tfh-like antigen-specific CD4( ) T cells during Plasmodium chabaudi infection

Jiun-Yu Jian, Shin-Ichi Inoue, Ganchimeg Bayarsaikhan, Mana Miyakoda, Daisuke Kimura, Kazumi Kimura, Eriko Nozaki, Takuya Sakurai, Daniel Fernandez-Ruiz, William R Heath, Katsuyuki Yui



Upon activation, specific CD4+ T cells up-regulate the expression of CD11a and CD49d, surrogate markers of pathogen-specific CD4+ T cells. However, using T-cell receptor transgenic mice specific for a Plasmodium antigen, termed PbT-II, we found that activated CD4+ T cells develop not only to CD11ahiCD49dhi cells, but also to CD11ahiCD49dlo cells during acute Plasmodium infection. CD49dhi PbT-II cells, localized in the red pulp of spleens, expressed transcription factor T-bet and produced IFN-γ, indicating that they were type 1 helper T (Th1)-type cells. In contrast, CD49dlo PbT-II cells resided in the white pulp/marginal zones and were a heterogeneous population, with approximately half of t..

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University of Melbourne Researchers


Awarded by Japan Society for the Promotion of Science

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (grant number 18K07094 to S.-I.I.; 18K19456, 19H03460 and 19KK0207 to K.Y.); the Ohyama Health Foundation Inc. and the Takeda Science Foundation to S.-I.I.; and National Health and Medical Research Council of Australia (grant numbers 1113293, 1139486 and 1154457) to W.R.H. and D.F.-R.