CD49d marks Th1 and Tfh-like antigen-specific CD4( ) T cells during Plasmodium chabaudi infection
Jiun-Yu Jian, Shin-Ichi Inoue, Ganchimeg Bayarsaikhan, Mana Miyakoda, Daisuke Kimura, Kazumi Kimura, Eriko Nozaki, Takuya Sakurai, Daniel Fernandez-Ruiz, William R Heath, Katsuyuki Yui
INTERNATIONAL IMMUNOLOGY | OXFORD UNIV PRESS | Published : 2021
Upon activation, specific CD4+ T cells up-regulate the expression of CD11a and CD49d, surrogate markers of pathogen-specific CD4+ T cells. However, using T-cell receptor transgenic mice specific for a Plasmodium antigen, termed PbT-II, we found that activated CD4+ T cells develop not only to CD11ahiCD49dhi cells, but also to CD11ahiCD49dlo cells during acute Plasmodium infection. CD49dhi PbT-II cells, localized in the red pulp of spleens, expressed transcription factor T-bet and produced IFN-γ, indicating that they were type 1 helper T (Th1)-type cells. In contrast, CD49dlo PbT-II cells resided in the white pulp/marginal zones and were a heterogeneous population, with approximately half of t..View full abstract
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Awarded by Japan Society for the Promotion of Science
Awarded by National Health and Medical Research Council of Australia
This work was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (grant number 18K07094 to S.-I.I.; 18K19456, 19H03460 and 19KK0207 to K.Y.); the Ohyama Health Foundation Inc. and the Takeda Science Foundation to S.-I.I.; and National Health and Medical Research Council of Australia (grant numbers 1113293, 1139486 and 1154457) to W.R.H. and D.F.-R.