Journal article

Apolipoprotein E homozygous? 4 allele status: Effects on cortical structure and white matter integrity in a young to mid-age sample

Janik Goltermann, Jonathan Repple, Ronny Redlich, Katharina Dohm, Claas Flint, Dominik Grotegerd, Lena Waltemate, Hannah Lemke, Stella Mercedes Fingas, Susanne Meinert, Verena Enneking, Tim Hahn, Jochen Bauer, Simon Schmitt, Tina Meller, Frederike Stein, Katharina Brosch, Olaf Steinstraeter, Andreas Jansen, Axel Krug Show all

EUROPEAN NEUROPSYCHOPHARMACOLOGY | ELSEVIER | Published : 2021

Abstract

Apolipoprotein E (APOE) genotype is the strongest single gene predictor of Alzheimer's disease (AD) and has been frequently associated with AD-related brain structural alterations before the onset of dementia. While previous research has primarily focused on hippocampal morphometry in relation to APOE, sporadic recent findings have questioned the specificity of the hippocampus and instead suggested more global effects on the brain. With the present study we aimed to investigate associations between homozygous APOE ε4 status and cortical gray matter structure as well as white matter microstructure. In our study, we contrasted n = 31 homozygous APOE ε4 carriers (age=34.47 years, including a su..

View full abstract

University of Melbourne Researchers

Grants

Funding Acknowledgements

This work is part of the German multicenter consortium "Neurobiology of Affective Disorders. A translational perspective on brain structure and function", funded by the German Research Foundation (Deutsche Forschungsgemeinschaft DFG; Forschungsgruppe/Research Unit FOR2107).r Principal investigators (PIs) with respective areas of responsibility in the FOR2107 consortium are:r Work Package WP1, FOR2107/MACS cohort and brain-imaging: Tilo Kircher (speaker FOR2107; DFG grant numbers KI 588/14-1, KI 588/14-2), Udo Dannlowski (co-speaker FOR2107; DA 1151/5-1, DA 1151/5-2), Axel Krug (KR 3822/5-1, KR 3822/7-2), Igor Nenadic (NE 2254/1-2), Carsten Konrad (KO 4291/3-1). WP5, genetics: Marcella Rietschel (RI 908/11-1, RI 908/11-2), Markus Nothen (NO 246/10-1, NO 246/10-2), Stephanie Witt (WI 3439/3-1, WI 3439/3-2). WP6, multi-method data analytics: Andreas Jansen (JA 1890/7-1, JA 1890/7-2), Tim Hahn (HA 7070/2-2), Bertram Muller-Myhsok (MU1315/8-2), Astrid Dempfle (DE 1614/3-1, DE 1614/3-2). CP1, biobank: Petra Pfefferle (PF 784/1-1, PF 784/1-2), Harald Renz (RE 737/20-1, 737/20-2). CP2, administration. Tilo Kircher (KI 588/15-1, KI 588/17-1), Udo Dannlowski (DA 1151/6-1), Carsten Konrad (KO 4291/4-1).