Association Between Inflammatory Biomarkers and Nonspecific Low Back Pain: A Systematic Review.
Yuan Z Lim, Yuanyuan Wang, Flavia M Cicuttini, Harrison J Hughes, Louisa Chou, Donna M Urquhart, Pei Xuan Ong, Sultana Monira Hussain
Clinical Journal of Pain | Lippincott, Williams & Wilkins | Published : 2020
OBJECTIVES: Chronic inflammation increases the production of cytokines and activates proinflammatory pathways which may lead to nonspecific low back pain (LBP). We systematically reviewed the literature to investigate whether inflammatory biomarkers are associated with nonspecific LBP. MATERIALS AND METHODS: CINAHL, Medline, and Embase were searched between January 1946 and May 2018. MeSH terms and key words were used to identify studies examining the association between inflammatory biomarkers and LBP. Two reviewers performed the risk of bias assessment and 3 reviewers extracted data independently. Qualitative evidence synthesis was performed. RESULTS: Thirteen studies, ranging from fair to..View full abstract