Duloxetine in Painful Diabetic Neuropathy: A Systematic Review.
Sultana Mehbuba Hossain, Sultana Monira Hussain, ARMS Ekram
Clinical Journal of Pain | Published : 2016
OBJECTIVE: To systematically review the evidence for duloxetine in the management of painful diabetic neuropathy (PDN). METHODS: Electronic searches of Medline and PubMed were performed from 2005 till October 2015 using medical subject headings and free-text words. Two independent reviewers extracted the data and assessed the methodological quality of the selected studies. RESULTS: Twenty-three studies met our inclusion criteria and 8 were considered of high quality and were included to this review. Because of heterogeneity of the studies included in this review, statistical pooling of the data was not possible. We found good evidence for use of duloxetine in PDN over placebo and pregabalin ..View full abstract