Associations between Genetically Predicted Circulating Protein Concentrations and Endometrial Cancer Risk.
Jingjing Zhu, Tracy A O'Mara, Duo Liu, Veronica Wendy Setiawan, Dylan Glubb, Amanda B Spurdle, Peter A Fasching, Diether Lambrechts, Daniel Buchanan, Pik Fang Kho, Linda S Cook, Christine Friedenreich, James V Lacey, Chu Chen, Nicolas Wentzensen, Immaculata De Vivo, Yan Sun, Jirong Long, Mengmeng Du, Xiao-Ou Shu Show all
Cancers | Published : 2021
Endometrial cancer (EC) is the leading female reproductive tract malignancy in developed countries. Currently, genome-wide association studies (GWAS) have identified 17 risk loci for EC. To identify novel EC-associated proteins, we used previously reported protein quantitative trait loci for 1434 plasma proteins as instruments to evaluate associations between genetically predicted circulating protein concentrations and EC risk. We studied 12,906 cases and 108,979 controls of European descent included in the Endometrial Cancer Association Consortium, the Epidemiology of Endometrial Cancer Consortium, and the UK Biobank. We observed associations between genetically predicted concentrations of ..View full abstract