Abnormal gene expression of BDNF, but not BDNF-AS, in iPSC, neural stem cells and postmortem brain samples from bipolar disorder
Tamaki Ishima, Sebastian Illes, Yoshimi Iwayama, Brian Dean, Takeo Yoshikawa, Hans Agren, Keiko Funa, Kenji Hashimoto
JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER | Published : 2021
BACKGROUND: Brain-derived neurotrophic factor (BDNF) antisense RNA (BDNF-AS) was identified as naturally conserved non-coding antisense RNA that suppresses the transcription of BDNF. METHODS: We measured the expression of BDNF mRNA and BDNF-AS mRNA in iPSC and NSC from bipolar disorder (BD) patients and healthy control subjects, and postmortem brain samples such as the corpus callosum, the Brodmann area (BA8), and BA46 from BD patients and age- and sex-matched controls. RESULTS: The expression of BDNF mRNA in iPSC from BD patients (n = 6) was significantly lower than that of control subjects (n = 4) although the expression of BDNF mRNA in NSC from BD patients was significantly higher than th..View full abstract
Awarded by MEXT
This study was supported by the GrantinAid for Scientific Research on Innovative Areas from the MEXT (19H05203 to K.H., 18H05435 to T. Y.) . The funding agency had no influence on study design, data collection, data analysis, interpretation, or writing of the report.