Journal article

A Randomized Clinical Trial to Compare Plasmodium falciparum Gametocytemia and Infectivity After Blood- Stage or Mosquito Bite Induced Controlled Malaria Infection

Manon Alkema, Isaie J Reuling, Gerdie M de Jong, Kjerstin Lanke, Luc E Coffeng, Geert-Jan van Gemert, Marga van de Vegte-Bolmer, Quirijn de Mast, Reinout van Crevel, Karen Ivinson, Christian F Ockenhouse, James S McCarthy, Robert Sauerwein, Katharine A Collins, Teun Bousema

JOURNAL OF INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2021

Abstract

BACKGROUND: For malaria elimination efforts, it is important to better understand parasite transmission to mosquitoes and develop models for early-clinical evaluation of transmission-blocking interventions. METHODS: In a randomized open-label trial, 24 participants were infected by bites from Plasmodium falciparum 3D7-infected mosquitoes (mosquito bite [MB]; n = 12) or by induced blood-stage malaria (IBSM) with the same parasite line (n = 12). After subcurative piperaquine treatment, asexual parasite and gametocytes kinetics were assessed, and mosquito feeding experiments were performed. RESULTS: Study procedures were well tolerated. The median peak gametocyte density was 1304/mL (interquart..

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University of Melbourne Researchers